Search results for "Anticancer treatment"

Acute leukemia following anticancer treatment

1975

Folate-targeted supramolecular vesicular aggregates as a new frontier for effective anticancer treatment in in vivo model.

2012

Abstract Supramolecular vesicular aggregates (SVAs), made up by self-assembling liposomes and polyasparthydrazide co-polymers conjugated to folic acid molecules were extensively investigated in this manuscript as potential active targeting formulation for anticancer drug delivery. Folate-targeted systems (FT-SVAs) were used to treat breast cancer and to further proof the potential in vivo administration of these systems for the therapeutic treatment for several aggressive solid tumors. The physicochemical and technological parameters of FT-SVAs are suitable for their potential in vivo administration. The chemotherapeutic activity of GEM-loaded FT-SVAs was increased during in vivo experiment…

Small molecule DNA-PK inhibitors as potential cancer therapy: a patent review (2010–present)

2021

Introduction: DNA-dependent protein kinase (DNA-PK) plays a crucial role in the repair of DSBs via non-homologous end joining (NHEJ). Several DNA-PK inhibitors are being investigated for potential anticancer treatment in clinical trials.Area covered: This review aims to give an overview of patents published since 2010 by analyzing the patent space and structure features of scaffolds used in those patents. It also discusses the recent clinical developments and provides perspectives on future challenges and directions in this field.Expert opinion: As a key component of the DNA damage response (DDR) pathway, DNA-PK appears to be a viable drug target for anticancer therapy. The clinical investi…

Characteristics of advanced cancer patients who were readmitted to an acute palliative/supportive care unit

2017

Objectives: The aim of this study was to assess the characteristics of patients readmitted to an acute supportive/palliative care unit (ASPCU), the reasons for readmission, and the outcome after receiving specialistic assessment and treatment. Methods: A consecutive sample of patients was assessed for a period of 10 months. Epidemiological characteristics, including age, gender, Karnofsky level, diagnosis, caregivers, education, disease awareness, kind of admission, and anticancer treatment in the previous 30 days, were recorded, as well as hospital stay, death, and discharge at home. The principal reasons for admission were recorded. Symptom intensity and opioid doses, expressed as oral …

Endocrine side-effects of new anticancer therapies: Overall monitoring and conclusions

2018

IF 0.795 (2017); International audience; The present final consensus statement of the French Society of Endocrinology lays out the assessments that are to be systematically performed before and during anticancer treatment by immunotherapy, tyrosine kinase inhibitors or mTOR inhibitors, even without onset of any endocrinopathy. It also discusses the CTCAE adverse event grading system in oncology and the difficulty of implementing it for endocrine side-effects of these anticancer treatments. Notably, this is why certain treatment steps applied in other side-effects (e.g., high-dose corticosteroids, contraindications to immunotherapy, etc.) need to be discussed before implementation for endocr…

Komplementāras terapijas lietošana pacientiem, kas saņem pretvēža ārstēšanu - biežums, anamnēzes dokumentācija, un iespējamā mijiedarbība ar terapiju

2015

Ievads Pētījuma mērķis bija komplementārās un alternatīvās medicīnas (KAM) pielietošanas analīze plaušu vēža pacientu vidū, kas saņem standarta pretvēža terapiju; izvērtēt, kāds KAM veids ir vispopulārākais, kāda ir pacientu motivācija to izmantot, kā arī novērtēt ar KAM saistītās priekšrocības, toksicitātes un riskus. Metodes Pētījumā tika iekļauti izplatīta sīkšūnu un ne-sīkšūnu plaušu vēža pacienti, kas saņem paliatīvu ķīmijterapiju un/vai staru terapiju Paula Stradiņa Klīniskās Universitātes Slimnīcas Onkoloģijas klīnikā (Rīga). Dalībniekiem tika piedāvāta aprakstoša anketa latviešu un krievu valodās. Atbilžu precizēšanai tika izmantotas pus-strukturētas intervijas. Dati par toksicitāti…

Usefulness of Stress Echocardiography in the Management of Patients Treated with Anticancer Drugs.

2021

In recent years, the survival of patients with cancer has improved thanks to advances in antineoplastic therapeutic protocols. This has led to an increasing burden of cardiovascular complications related to cancer treatment. Therefore, a new branch of cardiology has been created, ``cardio-oncology,'' with the aims of preventing cardiovascular complications related to antineoplastic treatment, achieving early diagnosis and treatment of any complications, and allowing completion of the expected antineoplastic treatment. Stress echocardiography has a pivotal role in achieving a timely diagnosis of coronary artery disease and thus is the best management approach in this clinical setting. Athero…